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51312-01178-Promising biological performance of biodegradable 3D coated Mg alloy bone scaffold

Mg alloy in the solid monolith form has been investigated as a promising orthopedic implant.  After 12 weeks of implantation (rabbits), significant bony tissue growth was observed both inside and outside the implants. These suggest the coated Mg alloy might be useful as a promising scaffold for bone repair and regeneration.

Product Number: 51312-01178-SG
ISBN: 01178 2012 CP
Author: XingGuo Cheng
Publication Date: 2012
$0.00
$20.00
$20.00

Mg alloy in the solid monolith form has been investigated as a promising orthopedic implant. Different coating techniques have also been developed to control the biocorrosion and improve biocompatibility. In the current study we designed novel 3D AZ31 Mg alloy scaffolds by rolling thin stiff sheets into hollow cylindrical scaffolds. The goal with these designed scaffolds was to mimic the basic shape of the cortical bone while reducing the amount of alloy used. These scaffolds were further layed with biocompatible coatings to improve their behavior. Finally they were tested in vitro using mesenchymal stem cells (MSCs) and in vivo using both rat and rabbit models. Our results demonstrated that coating not only altered significantly the biocorrosion behavior but also showed improved biocompatibility. After 12 weeks of implantation in a critical-size ulna defect in rabbits the scaffolds lead to different degree of radiographic unions and partial restoration of biomechanical strength in the defect. Quantification of serum C-reactive protein post-implantation indicated a moderate level of immune response to the implants. Significant bony tissue growth was observed both inside and outside the implants. These results suggest our designed and coated Mg alloy might be useful as a promising scaffold for bone repair and regeneration.

Key words: Mg alloy, bio-corrosion, bone, scaffold, protein, implant, micro-CT, X-ray Radiograph, SEMEDS,ELISA Assay, Histology

 

Mg alloy in the solid monolith form has been investigated as a promising orthopedic implant. Different coating techniques have also been developed to control the biocorrosion and improve biocompatibility. In the current study we designed novel 3D AZ31 Mg alloy scaffolds by rolling thin stiff sheets into hollow cylindrical scaffolds. The goal with these designed scaffolds was to mimic the basic shape of the cortical bone while reducing the amount of alloy used. These scaffolds were further layed with biocompatible coatings to improve their behavior. Finally they were tested in vitro using mesenchymal stem cells (MSCs) and in vivo using both rat and rabbit models. Our results demonstrated that coating not only altered significantly the biocorrosion behavior but also showed improved biocompatibility. After 12 weeks of implantation in a critical-size ulna defect in rabbits the scaffolds lead to different degree of radiographic unions and partial restoration of biomechanical strength in the defect. Quantification of serum C-reactive protein post-implantation indicated a moderate level of immune response to the implants. Significant bony tissue growth was observed both inside and outside the implants. These results suggest our designed and coated Mg alloy might be useful as a promising scaffold for bone repair and regeneration.

Key words: Mg alloy, bio-corrosion, bone, scaffold, protein, implant, micro-CT, X-ray Radiograph, SEMEDS,ELISA Assay, Histology

 

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